KMID : 0366220090440040320
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Korean Journal of Hematology 2009 Volume.44 No. 4 p.320 ~ p.324
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Generalized Primary Amyloid Lymphadenopathy
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Park Jin-Hyun
Kwon Ji-Hyun Kim Ji-Won Cho Hyeon-Jin Kim Ki-Hwan Chung Doo-Hyun Kim In-Ho Yoon Sung-Soo Park Seon-Yang Kim Byoung-Kook
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Abstract
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Systemic amyloidosis is a disease that displays deposition of insoluble polymeric protein fibrils in tissues and organs. We report here on a case of a 64-year-old woman who initially presented with multiple enlarged lymph nodes. Computed tomography showed multiple enlarged lymph nodes in the mediastinal, lower cervical, supraclavicular, axillary and abdominal areas. Excision biopsy of the cervical lymph nodes and the subsequent histopathology showed amorphous eosinophilic material deposits, and these revealed apple-green birefringence on a polarizing microscopic examination on the Congo-red stained slide. The patient was diagnosed with amyloidosis and she received chemotherapy consisting of melphalan and dexamethasone. During chemotherapy, she was diagnosed with breast cancer. After modified unilateral radical mastectomy, the dexamethasone was restarted and this therapy resulted in stable disease. (Korean J Hematol 2009;44:320-324.)
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KEYWORD
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Systemic amyloidosis, Multiple lymph node enlargement, Chemotherapy
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